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Semaglutide vs Tirzepatide

Semaglutide vs Tirzepatide

Semaglutide and Tirzepatide are compared here on the things that actually differ between them: what class each belongs to, what each acts on, how each is supplied and what each costs per milligram. Where the registry has no figure for one of them the row is left out rather than filled in.

3Semaglutide listings
4Tirzepatide listings
Reference only. This page covers what the compound is, how it is presented and how it is handled. It does not give dosing protocols or administration schedules, and it is not medical advice.

Side by side

SemaglutideTirzepatide
ClassGLP-1 receptor agonistDual GIP/GLP-1 receptor agonist
Acts onA GLP-1 analogue modified for albumin binding and resistance to DPP-4 degradation, giving a long circulating half-life relative to native GLP-1.Agonist at both the GIP and GLP-1 receptors, a mechanism distinct from single-receptor GLP-1 agonists such as semaglutide.
Supplied asLyophilised vial or pre-filled pen.Lyophilised vial or pre-filled pen.
Half-lifeApproximately seven days, supporting weekly intervals.Approximately five days in published pharmacokinetics.
StorageRefrigerated. Do not freeze.Refrigerated, protected from light. Not to be frozen.
Listings34
Price from£60£110

What actually differs

The clearest difference is class: Semaglutide is a GLP-1 receptor agonist, Tirzepatide is a dual GIP/GLP-1 receptor agonist. Half-life differs as well: Approximately seven days, supporting weekly intervals for Semaglutide against Approximately five days in published pharmacokinetics for Tirzepatide.

Stocked at The PED Shop

Availability checked 2026-09-09. The product page carries live stock.

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